Hassanandani is best known for acting in Balaji Telefilms and has also acted in Tamil, Hindi, Kannada, and Telugu films. After her success as a model for EverYuth, Sunsilk, Boroplus and other brands, she made her debut on the television screen in Ekta Kapoor's daytime soap Kabhii Sautan Kabhii Sahelii. She made her Hindi film debut with the 2003 Thriller film Kucch To Hai produced by Balaji Telefilms. She later worked for Balaji Telefilms again in the films Krishna Cottage, a supernatural thriller; and Koi Aap Sa. She also starred in the television show Kavyanjali, playing the protagonist Anjali, a middle class girl marrying into a business tycoon's family. Other than her mainstream Bollywood film and television screen performances, she also worked in some South Indian movies including 'Nenupelliki ready' and 'Thotti gang'. 'Nuvvu Nenu ' was a hit Telugu movie; later the movie was remade with the name Yeh Dil in Hindi with Ekta Kapoor's brother Tusshar Kapoor.